The Lowry houses the biggest public collection of works by LS Lowry. In 2000 it was transferred from its original home at Salford Art Gallery which.began collecting his work in the 1930s. The L S Lowry Collection now numbers arouind 350 paintings and drawings, ranging across Lowry's artistic careeer.

Different works from the Collection are shown, alongside pictures loaned from other public and private collections, in changing, themed exhibitions.